The Broad Institute is set to release version 4 of its Genome Analysis Toolkit (GATK) under an open source software license, ending a five-year experiment with a hybrid model. Broad switched to a ...

This work aims at addressing the question of whether the new CASAVA1.8, which boasts improvements such as local realignments of reads, is at par with the well accepted pipeline of BWA mapping, ...

Various methods have been developed for calling single-nucleotide polymorphisms from next-generation sequencing data. However, for satisfactory performance, most of these methods require expensive ...

The Broad Institute of MIT and Harvard is teaming up with Amazon Web Services, Cloudera, Google, IBM, Intel and Microsoft to provide its Genome Analysis Toolkit, which it calls GATK, as a cloud-based ...