The Lancet

Detection of young-onset type 2 diabetes using deep learning across primary and secondary care: a nationwide, retrospective cohort study

This study highlights the potential for using deep learning methods on longitudinal health data from both primary and ...

A vast Indigenous American genome map exposes lost migrations, ancient ancestry and more than a million new variants

Research into human genomic diversity has a number of applications in biomedicine, evolution, and history. However, many ...
eLife

Morphine regulates astrocyte transcriptional dynamics in the ventral tegmental area by stimulation of glucocorticoid signaling

Using single-nucleus RNA sequencing, the authors map transcriptional changes in the rat ventral tegmental area following chronic inflammatory pain and acute morphine exposure. Notably, their ...
eLife

Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization

HIV-1 envelope glycoprotein (Env), a gp120–gp41 trimer, undergoes coordinated conformational changes that drive membrane fusion and allow immune evasion by transiently concealing ...